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Salivary IgA has been proposed as a potential biomarker for gastrointestinal diseases. However, few studies have examined salivary IgA in patients with functional dyspepsia (FD) or gastroesophageal reflux disease (GERD). To investigate salivary IgA in patients with FD and GERD. We measured salivary IgA levels in patients with FD and GERD. A total of 187 patients with dyspeptic symptoms were analyzed. A total of 78 patients with FD were recruited, and 59 patients with GERD were enrolled. Salivary IgA was measured by a commercially available enzyme-linked immunosorbent assay. The characteristics of the patients were compared by the Mann-Whitney U test, χ2 test, or the Fisher exact test, as appropriate. The following were used to evaluate the diagnostic accuracy of salivary IgA: receiver operating characteristic curves, Pearson and Spearman correlations, and the area under the curve (AUC). Salivary IgA was significantly higher in patients with FD than in healthy subjects (P =.0016). The median concentrations of salivary IgA were 0.35 mg/dL (interquartile range [IQR], 0.22-0.77 mg/dL) in patients with FD and 0.12 mg/dL (IQR, 0.03-0.23 mg/dL) in healthy subjects (P 0b46394aab
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