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Our results indicate that the PET-NPLs that we have produced are not only harmless under the evaluated conditions, but also have shown that they are internalized by cells, indicating their potential to be bioavailable in the environment. This finding implies that the relevant contribution of MNPLs to the global plastic pollution is in the environment, and not in the human body. The case study of PET-NPLs here reported, in addition to reinforce the use of real samples, also shows that the analytical methodology used (dynamic light scattering and multi-angle light scattering with DLS/MAS-DLS) that we have proposed are particularly useful to characterize nano-environmental samples, and that it may also be applied to other plastic samples. The presented results are encouraging and suggest that PET-NPLs can be safely discarded in the environment, leaving the problem of plastic waste management for future developments.
To the best of our knowledge, this is the first report about the isolation of PET-NPLs and their effects on cellular uptake and genotoxicity. However, the use of nanomaterials may have implications for a variety of pathways, at both the organism and the cellular level. Therefore, it would be valuable to further explore the impact of these new materials on gene expression, signaling pathways, and protein-protein interactions.
Peer Group Questions – Think about the size of the private equity firm and the industry you are applying to. How did the firm decide to go with that size? Can you think of a situation where a firm would consider a different size? What kind of questions would you ask to determine whether a particular size or industry is right for you?
To decide which one should you opt for, one needs to look at the business as a whole. Doing so will give a better understanding of how the business functions, how profitable it is, how the management team is doing and what problems it might face in the future. It also helps to determine if there are any other reasons as to why you should or shouldn’t be interested in the company. Companies with a higher ROE are considered more attractive as well as have a higher Return on invested capital (ROIC). This helps determine if you need to invest in the company. 827ec27edc